FREE SHIPPING. Up to $10 OFF FOCUS PACKS for the launch of our NEW SITE

Effects of chronic treatment with methylphenidate on oxidative stress and inflammation in hippocampus of adult rats

Effects of chronic treatment with methylphenidate on oxidative stress and inflammation in hippocampus of adult rats

February 28, 2018

Motaghinejad M1Motevalian M2Shabab B3.

Source Article: https://www.ncbi.nlm.nih.gov/pubmed/26687276

 

Methylphenidate (MPH) is a central stimulant, prescribed for the treatment of attention deficit/hyperactivity disorder. The long-term behavioral consequences of MPH treatment are unknown. In this study, the oxidative stress and neuroinflammation induced by various doses of MPH were investigated. Forty adult male rats were divided into 5 groups; and treated with different doses of MPH for 21 days. Twenty four hours after drug treatment, Open Field Test (OFT) was performed in all animals. At the end of the study, blood cortisol level (BCL) was measured and hippocampus was isolated and oxidative stress and inflammation parameters and histological changes were analyzed. Chronic MPH at all doses decreased central square entries, number of rearing, ambulation distance and time spent in central square in OFT. BCL increased in doses 10 and 20mg/kg of MPH. Furthermore, MPH in all doses markedly increased lipid peroxidation, mitochondrial oxidized glutathione (GSSG) level, Interleukin 1β (IL-1β) and Tumor Necrosis Factor α (TNF-α) in isolated hippocampus. MPH (10 and 20mg/kg) treated groups had decreased mitochondrial reduced glutathione(GSH) content, and reduced superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRx) activities. 10 and 20mg/kg of MPH change cell density and morphology of cells in Dentate Gyrus (DG) and CA1 areas of hippocampus. Chronic treatment with high doses of MPH can cause oxidative stress, neuroinflammation and neurodegeneration in hippocampus of adult rats.



Leave a comment


Also in ADHD Natural News

Student with ADHD says horseback riding helps control the disorder
Student with ADHD says horseback riding helps control the disorder

June 15, 2018

Read More

Why ADHD Drug Overdoses Are Rising Among U.S. Children
Why ADHD Drug Overdoses Are Rising Among U.S. Children

May 23, 2018

Read More

What everyone gets wrong about ADHD — and how it can be used as a superpower
What everyone gets wrong about ADHD — and how it can be used as a superpower

May 17, 2018

There is another way of thinking about ADHD. It is a kind of variation that humanity needs, she said, because every society needs people who are "settlers," and also those who are "explorers."

Read More

Try our Newsletter

Special discounts, new products and natural ADHD related information.