FREE SHIPPING. Up to $10 OFF FOCUS PACKS for the launch of our NEW SITE

Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder

Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder

February 28, 2018

Bradstreet JJ1Smith SBaral MRossignol DA.

Source Article: https://www.ncbi.nlm.nih.gov/pubmed/20359266

 

Abstract

Autism spectrum disorders (ASD) and attention-deficit hyperactivity disorder (ADHD) are common and complex neurodevelopmental conditions. Diagnostic criteria for these conditions have traditionally relied solely on behavioral criteria without consideration for potential biomedical underpinnings. Newer evidence, however, reveals that ASDs are associated with: oxidative stress; decreased methylation capacity; limited production of glutathione; mitochondrial dysfunction; intestinal dysbiosis; increased toxic metal burden; immune dysregulation, characterized by a unique inflammatory bowel disease and immune activation of neuroglial cells; and ongoing brain hypoperfusion. Many of these same problems are common features in children with ADHD. These medical conditions, whether co-morbidities or etiopathogenic, would be expected to have synergistically negative effects on the development, cognition, focus, and attention of affected children. It is likely these biological abnormalities contribute significantly to the behavioral symptoms intrinsic in these diagnoses. However, treatment for these underlying medical disorders is clinically justified, even if no clear immediate behavioral improvements are observed. This article reviews the medical literature and discusses the authors clinical experience using various biomarkers for measuring oxidative stress, methylation capacity and transsulfuration, immune function, gastrointestinal problems, and toxic metal burden. These biomarkers provide useful guides for selection, efficacy, and sufficiency of biomedical interventions. The use of these biomarkers is of great importance in young children with ADHD or individuals of any age with ASD, because typically they cannot adequately communicate regarding their symptoms.



Leave a comment


Also in ADHD Natural News

There Are Nearly 1,000 Chemicals in Our Food That Have Never Been Tested for Safety
There Are Nearly 1,000 Chemicals in Our Food That Have Never Been Tested for Safety

September 20, 2018

Read More

Nutritionally Speaking: Got Cognitive Function?
Nutritionally Speaking: Got Cognitive Function?

August 20, 2018

Studies show that children diagnosed with ADHD typically have diets high in sugar (mine was), low in protein, and are also deficient in EFA's (essential fatty acids), particularly Omega 3 fats as found in flax, chia and hemp seed, as well as cold water fish oils, pasture raised chicken eggs and meat. 

Read More

In Praise of A.D.H.D.
In Praise of A.D.H.D.

August 10, 2018

To thrive in this frenetic world, certain cognitive tendencies are useful: to embrace novelty, to absorb a wide variety of information, to generate new ideas. The possibility that such characteristics might be associated with A.D.H.D. 

Read More

Try our Newsletter

Special discounts, new products and natural ADHD related information.